BNCT dosimetric study of head tumor cases based on Monte Carlo methods

Peng Heyu; Zheng Qi; Wang Wei; He Qingming; Cao Liangzhi; Zu Tiejun; Wang Yongping

doi:10.11884/HPLPB202638.250291

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Peng Heyu, Zheng Qi, Wang Wei, et al. BNCT dosimetric study of head tumor cases based on Monte Carlo methods[J]. High Power Laser and Particle Beams. doi: 10.11884/HPLPB202638.250291

Citation:

Peng Heyu, Zheng Qi, Wang Wei, et al. BNCT dosimetric study of head tumor cases based on Monte Carlo methods[J]. High Power Laser and Particle Beams. doi: 10.11884/HPLPB202638.250291

Peng Heyu, Zheng Qi, Wang Wei, et al. BNCT dosimetric study of head tumor cases based on Monte Carlo methods[J]. High Power Laser and Particle Beams. doi: 10.11884/HPLPB202638.250291

Citation:

Peng Heyu, Zheng Qi, Wang Wei, et al. BNCT dosimetric study of head tumor cases based on Monte Carlo methods[J]. High Power Laser and Particle Beams. doi: 10.11884/HPLPB202638.250291

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BNCT dosimetric study of head tumor cases based on Monte Carlo methods

doi: 10.11884/HPLPB202638.250291

School of Nuclear Science and Technology Xi'an Jiaotong University, Xi’an 710049, China

Received Date: 2025-09-08
Accepted Date: 2025-12-25
Rev Recd Date: 2025-12-29

Available Online: 2026-01-21

Abstract

Abstract

Background
Boron Neutron Capture Therapy (BNCT) is an innovative binary targeted cancer treatment technology with high relative biological effect and cell-scale precision, but its clinical application is limited by the long computation time of traditional Monte Carlo methods for dose calculation and insufficient dosimetric research on head tumors.
Purpose
This study aims to address these challenges by optimizing the Monte Carlo algorithm and developing pre-processing/post-processing modules, verifying the accuracy of the computational system, and analyzing the dosimetric characteristics of BNCT for head tumors.
Methods
Based on NECP-MCX, three acceleration strategies voxel geometry fast tracking, transport-counting integration, MPI parallel optimization were adopted to improve computational efficiency. Pre-processing (DICOM image parsing, material-boron concentration mapping, 3D voxel modeling) and post-processing (dose-depth curve, Dose-Volume Histogram (DVH), dose distribution cloud map) modules were developed. Both NECP-MCX and MCNP were used to calculate the dose distribution of a head tumor case (RADCURE-700) for comparison.
Results
The single-dose calculation time was reduced from 2 hours to 9.4 minutes. The dose curves, DVH, and cloud maps from the two programs showed good consistency with relative deviations below 5% within 10 cm depth. BNCT achieved a tumor target volume D₉₀ of 60 Gy in 63 minutes, with healthy tissue dose below 12.5 Gy.
Conclusions
The optimized NECP-MCX system realizes efficient and accurate dose calculation for BNCT. The consistent results validate its reliability, and the dosimetric analysis demonstrates BNCT’s potential for head tumor treatment, providing methodological support for clinical treatment planning.
- Radiation dose,
- Monte Carlo,
- Boron Neutron Capture Therapy (BNCT),
- Case study

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References(19)

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