Abstract: A nonlinear transmission line-based pulse-sharpening system with output pulse of high voltage into 50 for repetitive operation is developed. This paper describes the theory and design procedures of ferrite-loaded transmission line which is used to produce sub-nanosecond rise time electrical pulse with high power. The design parameters based on ferrite-loaded line are presented. In experiment, different factors on the fact of sharpening are analyzed. The experiment results show the pulse sharpening effect varies with different ferrite materials. It helps the final selecting of the most efficient ferrite material, the ferrite with higher saturation magnetization. The experiment results indicate that the axial bias is very important for the pulse sharpening. There is a best value of the axial bias for the fastest front of pulse. After optimization, an output pulse of 450 ps, 39 kV is obtained at load for high repetitive operation.