Abstract: The mini-channel cooling system with cylinder disturbed flow is proposed for highpower laser cooling. Using deionized-water as working fluid, heat transfer and pressure drop characters of mini-channel heat radiators with and without disturbed flow are experimentally studied. It is found that the pressure drop per unit length is proportional to Reynolds number, and the disturbed flow has the slight effect on pressure drop. There is an optimal Reynolds number at which the difference of transfer performance between these two kinds of radiators are largest. General empirical formulas are proposed to evaluate heat transfer performance of mini-channel radiators with consideration of Nusselt number as functions of Reynolds number in the mini-channels with and without disturbed flow. The thermal