Abstract: For accelerator driven sub-critical system (ADS) injector Ⅱ, we studied its fast protection system and timing system, and designed a PXIe controller which could be used to construct fast protection system and timing system. The PXIe controller could achieve optical fiber communication, PXIe bus communication, delay trigger signal output function, etc. Among them, the optical fiber communication function is used to achieve data transmission between each PXIe controller; PXIe bus communication function is primarily used to achieve data exchange between the controller and IPC; delayed trigger signal output function can give precise timing trigger signals, which can ensure all subsystems and equipments work in accordance with certain timing.