Abstract: Seismic fragility analysis brings in fragility curves which show the probability of structural damage due to earthquake as a function of ground motion indices. In order to evaluate the seismic fragility of Shenguang-Ⅲ target building, the paper performs a series of nonlinear time-history analyses on the target building subjected to the Wenchuan earthquake waves supplied by China National Strong Motion Network Center. Besides, the damage index is the maximum interlayer drift angle, and the earthquake intensity index is PGA (Peak Ground Acceleration). Based on the seismic fragility analysis method, the seismic fragility curves and matrix are obtained. At last, the damage probabilities of Shenguang-Ⅲ target building are calculated according to the seismic fragility curves under seismic fortification intensities eight and nine. The result shows that the damage probability of Shenguang-Ⅲ target building is very small.