Abstract: Large number and variety of instruments with complex interfaces are the main characteristics of the measurement and control system in multi-pulse and high-current linear induction accelerator(LIA). The instruments are divided into distinct subsystems according to their function, and the instruments in each subsystem are joined to the model of protocol transition, and then linked with the local server in the network of the measurement and control system. The software of communication and control for instruments is programmed based on LabVIEW. VISA library and UDP protocol are applied to the software in local server, and DataSocket protocol is applied to the remote communication. Circuits of power supply and charger to Marx are heavily insulated against the electromagnetic disturbance and high voltage strike. For improving reliability, network structure and data flows are optimized, UDP protocols are applied, and master-slave pattern is also applied to bus arbitration. The system runs steadily and reliably in multi-pulse and high-current LIA by this time.