Study of electron FLASH radiotherapy dose measurement based on EBT3 film

Wang Shilan; Yang Yiwei; Cheng Deqi; Tang Leixun; Wu Dai

doi:10.11884/HPLPB202436.240095

Volume 36 Issue 12

Nov. 2024

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Wang Shilan, Yang Yiwei, Cheng Deqi, et al. Study of electron FLASH radiotherapy dose measurement based on EBT3 film[J]. High Power Laser and Particle Beams, 2024, 36: 126005. doi: 10.11884/HPLPB202436.240095

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Wang Shilan, Yang Yiwei, Cheng Deqi, et al. Study of electron FLASH radiotherapy dose measurement based on EBT3 film[J]. High Power Laser and Particle Beams, 2024, 36: 126005. doi: 10.11884/HPLPB202436.240095

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Study of electron FLASH radiotherapy dose measurement based on EBT3 film

doi: 10.11884/HPLPB202436.240095

Wang Shilan^1
,,
Yang Yiwei^{1
,
,},
Cheng Deqi²,
Tang Leixun³,
Wu Dai^{1
,
,}

1.
Institute of Applied Electronics, CAEP, Mianyang 621900, China
2.
College of Nuclear Science and Technology, Harbin Engineering University, Harbin 150001, China
3.
School of Nuclear Science and Technology, University of South China, Hengyang 421001, China

Received Date: 2024-03-14
Accepted Date: 2024-09-02
Rev Recd Date: 2024-09-14

Available Online: 2024-09-23

Publish Date: 2024-11-08

Abstract

Abstract

FLASH radiotherapy delivers the entire dose to the target area within milliseconds using ultra-high dose rates, rendering existing online dosimeters essentially ineffective. Currently, radiation-sensitive films are commonly employed for dose measurement. Utilizing an electron accelerator developed by the Institute of Applied Electronics of CAEP, an electron FLASH radiotherapy platform was established to investigate the dose rate range and dose distribution using the EBT3 film’s rapid readout method. Experimental results indicate that the rapid readout method of EBT3 films is applicable for dose measurement in electron FLASH radiotherapy, with dose rates ranging from 240 Gy/s to 290 Gy/s at a source-to-skin distance of 100 cm and a depth of 1 cm. Fluctuations in the average energy of the electron beam reaching the surface of the phantom result in dose fluctuations of approximately ±5% in the target area. The surface dose distribution meets the requirements of flatness within ±5% and symmetry within ±3%.
- radiation therapy,
- ultra-high dose rate,
- Gafchromic EBT3,
- dosimetry,
- electron FLASH radiotherapy platform

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References(30)

References

[1]	高峰, 曹璐璐, 羊奕伟, 等. 基于PARTER开展肿瘤Flash-RT研究——设计及计算[J]. 中国医学物理学杂志, 2020, 37(9):1081-1087 doi: 10.3969/j.issn.1005-202X.2020.09.001 Gao Feng, Cao Lulu, Yang Yiwei, et al. Design and calculation of Flash-RT based on PARTER[J]. Chinese Journal of Medical Physics, 2020, 37(9): 1081-1087 doi: 10.3969/j.issn.1005-202X.2020.09.001
[2]	Ramish Ashraf M, Rahman M, Zhang Rongxiao, et al. Dosimetry for FLASH radiotherapy: a review of tools and the role of radioluminescence and cherenkov emission[J]. Frontiers in Physics, 2020, 8: 328. doi: 10.3389/fphy.2020.00328
[3]	McManus M, Romano F, Lee N D, et al. The challenge of ionisation chamber dosimetry in ultra-short pulsed high dose-rate Very High Energy Electron beams[J]. Scientific Reports, 2020, 10: 9089. doi: 10.1038/s41598-020-65819-y
[4]	Favaudon V, Lentz J M, Heinrich S, et al. Time-resolved dosimetry of pulsed electron beams in very high dose-rate, FLASH irradiation for radiotherapy preclinical studies[J]. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2019, 944: 162537. doi: 10.1016/j.nima.2019.162537
[5]	Chabi S, Van To T H, Leavitt R, et al. Ultra-high-dose-rate FLASH and conventional-dose-rate irradiation differentially affect human acute lymphoblastic leukemia and normal hematopoiesis[J]. International Journal of Radiation Oncology·Biology·Physics, 2021, 109(3): 819-829.
[6]	Zhu Hongyu, Xie Dehuan, Wang Ying, et al. Comparison of intratumor and local immune response between MV X-ray FLASH and conventional radiotherapies[J]. Clinical and Translational Radiation Oncology, 2023, 38: 138-146. doi: 10.1016/j.ctro.2022.11.005
[7]	Vozenin M C, De Fornel P, Petersson K, et al. The advantage of FLASH radiotherapy confirmed in mini-pig and cat-cancer patients[J]. Clinical Cancer Research, 2019, 25(1): 35-42. doi: 10.1158/1078-0432.CCR-17-3375
[8]	Schüler E, Trovati S, King G, et al. Experimental platform for ultra-high dose rate flash irradiation of small animals using a clinical linear accelerator[J]. International Journal of Radiation Oncology·Biology·Physics, 2017, 97(1): 195-203.
[9]	Montay-Gruel P, Petersson K, Jaccard M, et al. Irradiation in a flash: unique sparing of memory in mice after whole brain irradiation with dose rates above 100 Gy/s[J]. Radiotherapy and Oncology, 2017, 124(3): 365-369. doi: 10.1016/j.radonc.2017.05.003
[10]	Petersson K, Jaccard M, Germond J F, et al. High dose-per-pulse electron beam dosimetry - A model to correct for the ion recombination in the Advanced Markus ionization chamber[J]. Medical Physics, 2017, 44(3): 11571167.
[11]	Gotz M, Karsch L, Pawelke J. A new model for volume recombination in plane-parallel chambers in pulsed fields of high dose-per-pulse[J]. Physics in Medicine & Biology, 2017, 62(22): 8634-8654.
[12]	Marinelli M, Felici G, Galante F, et al. Design, realization, and characterization of a novel diamond detector prototype for FLASH radiotherapy dosimetry[J]. Medical Physics, 2022, 49(3): 1902-1910. doi: 10.1002/mp.15473
[13]	Velthuis J J, Page R F, Purves T M, et al. Toward pulse by pulse dosimetry using an SC CVD diamond detector[J]. IEEE Transactions on Radiation and Plasma Medical Sciences, 2017, 1(6): 527-533. doi: 10.1109/TRPMS.2017.2750799
[14]	Khanna R, James R, Hugtenburg R. Diamond dosimeter development for real-time microdosimetry and its use in FLASH RT[J]. Physica Medica, 2022, 94 Suppl 1: S102.
[15]	Bourgouin A, Schüller A, Hackel T, et al. Calorimeter for real-time dosimetry of pulsed ultra-high dose rate electron beams[J]. Frontiers in Physics, 2020, 8: 567340. doi: 10.3389/fphy.2020.567340
[16]	Bisogni M G. Inoriganic scintillators development and test of LYSO detector prototype[R]. FRPT 2021.
[17]	Favaudon V, Caplier L, Monceau V, et al. Ultrahigh dose-rate FLASH irradiation increases the differential response between normal and tumor tissue in mice[J]. Science Translational Medicine, 2014, 6: 245ra93.
[18]	Niroomand-Rad A, Chiu-Tsao S T, Grams M P, et al. Report of AAPM Task Group 235 radiochromic film dosimetry: an update to TG-55[J]. Medical Physics, 2020, 47(12): 5986-6025. doi: 10.1002/mp.14497
[19]	Liu K, Jorge P G, Tailor R, et al. Comprehensive evaluation and new recommendations in the use of Gafchromic EBT3 film[J]. Medical Physics, 2023, 50(11): 7252-7262. doi: 10.1002/mp.16593
[20]	Lewis D F, Chan M F. Technical Note: on GAFChromic EBT-XD film and the lateral response artifact[J]. Medical Physics, 2016, 43(2): 643-649. doi: 10.1118/1.4939226
[21]	Palmer A L, Bradley D A, Nisbet A. Evaluation and mitigation of potential errors in radiochromic film dosimetry due to film curvature at scanning[J]. Journal of Applied Clinical Medical Physics, 2015, 16(2): 425-431. doi: 10.1120/jacmp.v16i2.5141
[22]	Borca V C, Pasquino M, Russo G, et al. Dosimetric characterization and use of GAFCHROMIC EBT3 film for IMRT dose verification[J]. Journal of Applied Clinical Medical Physics, 2013, 14(2): 158-171. doi: 10.1120/jacmp.v14i2.4111
[23]	van Battum L J, Hoffmans D, Piersma H, et al. Accurate dosimetry with GafChromic™ EBT film of a 6 MV photon beam in water: what level is achievable?[J]. Medical Physics, 2008, 35(2): 704-716. doi: 10.1118/1.2828196
[24]	Devic S, Seuntjens J, Hegyi G, et al. Dosimetric properties of improved GafChromic films for seven different digitizers[J]. Medical Physics, 2004, 31(9): 2392-2401. doi: 10.1118/1.1776691
[25]	Sukhikh E, Sukhikh L, Malikov E, et al. Uncertainty of measurement absorbed dose by GAFCHROMIC EBT3 dosimeter for clinical electron and photon beams of medical accelerators[J]. Medical Radiology and Radiation Safety, 2019, 64(4): 56-63.
[26]	Sharma M, Singh R, Robert N, et al. Beam quality and dose rate dependency of Gafchromic EBT3 film irradiated with therapeutic megavolt photon beams[J]. Radiation Measurements, 2021, 146: 106632. doi: 10.1016/j.radmeas.2021.106632
[27]	Ferreira B C, Lopes M C, Capela M. Evaluation of an Epson flatbed scanner to read Gafchromic EBT films for radiation dosimetry[J]. Physics in Medicine & Biology, 2009, 54(4): 1073-1085.
[28]	周婉仪, 宫辉, 邱睿, 等. 金刚石探测器在Flash照射实时剂量测量中的应用[J]. 中华放射医学与防护杂志, 2023, 43(9):729-735 doi: 10.3760/cma.j.cn112271-20230216-00036 Zhou Wanyi, Gong Hui, Qiu Rui, et al. Feasibility of diamond detector on Flash radiation dosimetry online[J]. Chinese Journal of Radiological Medicine and Protection, 2023, 43(9): 729-735 doi: 10.3760/cma.j.cn112271-20230216-00036
[29]	翁邓胡, 徐海荣. 高能电子束放射治疗的研究进展[J]. 中国辐射卫生, 2011, 20(3):375-378 Weng Denghu, Xu Hairong. Research progress in high-energy electron beam radiation therapy[J]. Chinese Journal of Radiological Health, 2011, 20(3): 375-378
[30]	Musolino S V. Absorbed dose determination in external beam radiotherapy: an international code of practice for dosimetry based on standards of absorbed dose to water; Technical Reports Series No. 398[J]. Health Physics, 2001, 81(5): 592-593.