A set of airborne high-resolution all-sphere midwave infrared optical system was designed based on the advanced staring focal plane array which had a format of 640480 and the pixel pitch of 15 m. The working wavelength is in 3-5 m, the full field of view is 8.58, the relative aperture is 1/2, and the efficient focal length is 80 mm. The optical system adopted four lenses with three kinds of materialGe, ZnSe and Si. All surfaces are spherical, instead of the diffractive surface and aspheric surface used in traditional systems, and it is more easy to process and test. The design results prove that, the midwave infrared optical system has compact structure, small volume, high resolution, and excellent image quality, meeting the design requirements, and it could be used in airborne photoelectric detection and tracking systems.