zhou zhou, zhang lei, li mao-quan, et al. Cardic injury induced by X-band microwave irradiation in rats and its mechanism[J]. High Power Laser and Particle Beams, 2006, 18.
Citation:
zhou zhou, zhang lei, li mao-quan, et al. Cardic injury induced by X-band microwave irradiation in rats and its mechanism[J]. High Power Laser and Particle Beams, 2006, 18.
zhou zhou, zhang lei, li mao-quan, et al. Cardic injury induced by X-band microwave irradiation in rats and its mechanism[J]. High Power Laser and Particle Beams, 2006, 18.
Citation:
zhou zhou, zhang lei, li mao-quan, et al. Cardic injury induced by X-band microwave irradiation in rats and its mechanism[J]. High Power Laser and Particle Beams, 2006, 18.
Wistar rats were exposed to 90W/cm2 X-band HPM irradiation for 10 minutes. Myocardial tissues were collected at 0, 0.5, 1, 3, 6, 12, 24 h post exposure. The histopathological changes were observed with light microscope. The cardiomyocytes apoptosis were determined by TUNEL method. The changes of GSK-3β, caspase-9 and caspase-3 mRNA expression in rat myocardium after 90 W/cm2 HPM irradiation were determined by using RT-PCR. The changes of GSK-3β phosphorylation were determined by using western blotting. The changes of caspase-9 enzymes activity induced by HPM irradiation were assessed via a colorimetric assay utilizing specific substrates. X-band microwave irradiation can induce cardiomyocyte apoptosis. HPM also leads to obvious activation of GSK3β and coupled signal transduction pathway
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