Based on the Whispering Gallery Mode, a kind of laser with intrinsic high quality factor and low threshold can be obtained, which is called microsphere laser. It is widely applied in many fields such as microcavity quantum electric dynamics, optical fiber communication, sensors, nonlinear optics, low threshold laser equipment and quantum optics due to its sensitivity to pressure and temperature.In this paper, the principle and the method to produce the microsphere laser and its characters, applications and newly development are reviewed.