1064 nm laser induced thermal injure in mice skin with different laser duration

Zhou Xun; Ma Qiong; Liu Zhibo; Kang Hongxiang

doi:10.11884/HPLPB202234.210338

Volume 34 Issue 1

Jan. 2022

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Zhou Xun, Ma Qiong, Liu Zhibo, et al. 1064 nm laser induced thermal injure in mice skin with different laser duration[J]. High Power Laser and Particle Beams, 2022, 34: 011012. doi: 10.11884/HPLPB202234.210338

Citation:

Zhou Xun, Ma Qiong, Liu Zhibo, et al. 1064 nm laser induced thermal injure in mice skin with different laser duration[J]. High Power Laser and Particle Beams, 2022, 34: 011012. doi: 10.11884/HPLPB202234.210338

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1064 nm laser induced thermal injure in mice skin with different laser duration

doi: 10.11884/HPLPB202234.210338

Zhou Xun^{1, 2
,},
Ma Qiong¹,
Liu Zhibo¹,
Kang Hongxiang^{1
,
,}

1.
Institute of Radiation Medicine, Academy of Military Medical Science, Academy of Military Science PLA China, Beijing100850, China
2.
Information and Communication Engineering College, North University of China, Taiyuan 030051, China

Received Date: 2021-08-01
Rev Recd Date: 2021-12-24

Available Online: 2021-12-29

Publish Date: 2022-01-15

Abstract

Abstract

To explore laser induced thermal injure in skin tissue, 1064 nm laser induced thermal injure in mice skin with different laser duration was studied by experimental and theoretical analysis methods. Dermoscope images and optical coherence tomography images were used to assess the degree of thermal injure in biological skin tissue. Arrhenius thermal injure equation was used to calculate thermal damage parameters and establish a laser induced thermal injure model of skin tissue, then compared with experimental results. The results show that under the 1064 nm laser irradiation with 30 W/mm² power density, there was reversible damage in the mouse skin tissue within 0 to 100 ms laser duration; the mice skin tissue appeared edema and thermal coagulation injure within 150 to 280 ms laser duration; during the laser duration of 280 to 550 ms, the epidermis of the mice skin was vaporized, eschars appeared around the damage spot, and the dermis was degenerated. Over 660 ms laser duration, the epidermis and dermis of the mice skin were vaporized, tissue fluid was exuded from the wound and the subcutaneous tissue was degenerated. The theoretical analysis is consistent with the experimental results. The established thermal injury model can verify the degree of thermal injury in mice skin.
- 1064 nm laser,
- thermal injure,
- classification of thermal injure,
- thermal injure equation,
- thermal injure model

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References(15)

References

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