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He Xu, Ma Yuncan, Guo Weiwei, et al. Research progress on femtosecond laser processing technology for high-performance implants[J]. High Power Laser and Particle Beams. doi: 10.11884/HPLPB202638.250323
Citation: He Xu, Ma Yuncan, Guo Weiwei, et al. Research progress on femtosecond laser processing technology for high-performance implants[J]. High Power Laser and Particle Beams. doi: 10.11884/HPLPB202638.250323

Research progress on femtosecond laser processing technology for high-performance implants

doi: 10.11884/HPLPB202638.250323
  • Received Date: 2025-09-30
  • Accepted Date: 2026-02-10
  • Rev Recd Date: 2026-02-15
  • Available Online: 2026-03-12
  • Titanium and its alloys are the predominant base materials for oral implants. However, challenges such as prolonged osseointegration periods and limited success rates persist due to their inherent low surface bioactivity. Femtosecond laser processing has emerged as an innovative, non-thermal, and high-precision surface modification technique, offering a novel approach to precisely tailor the micro-nano topography, chemical composition, and biological performance of implant surfaces. This review summarizes research advances in femtosecond laser surface treatment of titanium implants over the past five years. It systematically elaborates on methods for constructing specific surface architectures by regulating parameters such as laser power, wavelength, scanning strategies, and pulse patterns. Furthermore, it introduces hybrid processing strategies that combine femtosecond laser with techniques like hydroxyapatite deposition, sandblasting, and 3D printing, highlighting their synergistic effects. By comparing femtosecond laser processing with conventional surface treatment technologies (e.g., sandblasting and acid etching, electrochemical deposition, plasma sputtering), this paper analyzes its unique advantages in terms of processing precision, heat-affected zone, biocompatibility, and long-term stability. Finally, current challenges (e.g., equipment cost, processing efficiency) are summarized, and future development directions are proposed, including personalized implant manufacturing, multifunctional surface construction, and integration with other advanced technologies.
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  • [1]
    Geetha M, Singh A K, Asokamani R, et al. Ti based biomaterials, the ultimate choice for orthopaedic implants – A review[J]. Progress in Materials Science, 2009, 54(3): 397-425. doi: 10.1016/j.pmatsci.2008.06.004
    [2]
    Nicholson J W. Titanium alloys for dental implants: a review[J]. Prosthesis, 2020, 2(2): 100-116. doi: 10.3390/prosthesis2020011
    [3]
    De Santis S, Varricchio R, Ceccucci A, et al. Cerium coatings on pristine and nanostructured Ti and Ti6Al4V surfaces: bioactivity, resistance in simulated inflammatory conditions, and antibacterial performance[J]. ACS Biomaterials Science & Engineering, 2023, 9(6): 3262-3272. doi: 10.1021/acsbiomaterials.2c01461
    [4]
    Xu Lurun, Tao Jingchao, Li Zhuguo, et al. Femtosecond laser ultrafast photothermal exsolution[J]. International Journal of Extreme Manufacturing, 2024, 6: 055002. doi: 10.1088/2631-7990/ad4eb0
    [5]
    Liu Ruijie, Zhang Dongshi, Li Zhuguo. Femtosecond laser subtractive/additive-integrated biomimetic manufacturing for visible/infrared encryption and stimuli-responsive infrared decryption[J]. International Journal of Extreme Manufacturing, 2025, 7: 045009. doi: 10.1088/2631-7990/adc87f
    [6]
    Zhao Hualong, Zhu Wenyu, Yang Xiaojun, et al. A study of femtosecond laser machining technology applied in air-film holes on turbine blades[J]. Applied Mechanics and Materials, 2012, 268/270: 487-491.
    [7]
    Yang Zenan, Ji Pengfei, Zhang Zhen, et al. Fundamental 3D simulation of the femtosecond laser ablation for cooling hole drilling on Ni and Fe based aero-engine components[J]. Optics Communications, 2020, 475: 126237. doi: 10.1016/j.optcom.2020.126237
    [8]
    Guarnaccio A, Belviso C, Montano P, et al. Femtosecond laser surface texturing of polypropylene copolymer for automotive paint applications[J]. Surface and Coatings Technology, 2021, 406: 126727. doi: 10.1016/j.surfcoat.2020.126727
    [9]
    徐艳龙, 李文戈, 赵远涛, 等. 激光毛化织构铝合金表面润湿性的研究进展[J]. 强激光与粒子束, 2025, 37: 121001

    Xu Yanlong, Li Wenge, Zhao Yuantao, et al. Research progress on wettability of laser-textured aluminum alloy surfaces[J]. High Power Laser and Particle Beams, 2025, 37: 121001
    [10]
    雍佳乐, 吴东. 飞秒激光仿生调控材料表面浸润性: 当前进展与挑战(特邀)[J]. 中国激光, 2024, 51: 0102002 doi: 10.3788/CJL231364

    Yong Jiale, Wu Dong. Bioinspired controlling the surface wettability of materials by femtosecond laser: current progress and challenges (Invited)[J]. Chinese Journal of Lasers, 2024, 51: 0102002 doi: 10.3788/CJL231364
    [11]
    马杰, 胡梦云, 李爽, 等. 飞秒激光表面处理铝合金的热工艺对比研究(特邀)[J]. 激光与光电子学进展, 2026, 63: 0314025 doi: 10.3788/LOP252206

    Ma Jie, Hu Mengyun, Li Shuang, et al. Comparative study of thermal processes for surface treatment of aluminum alloy using femtosecond laser (Invited)[J]. Laser & Optoelectronics Progress, 2026, 63: 0314025 doi: 10.3788/LOP252206
    [12]
    Sun Xiaomao, Dong Xia, Wang Kedian, et al. Femtosecond laser processing of controlled tapered micro-holes based on dynamic control of relative attitude[J]. Optics & Laser Technology, 2024, 170: 110201. doi: 10.1016/j.optlastec.2023.110201
    [13]
    Xu Tianshu, Wei Ran, Singh S C, et al. 15-Fold increase in solar thermoelectric generator performance through femtosecond-laser spectral engineering and thermal management[J]. Light: Science & Applications, 2025, 14: 268.
    [14]
    Li Quansheng, Sun Xiaofei, Mei Xuesong, et al. High-quality femtosecond laser cutting of battery electrodes with enhanced electrochemical performance by regulating the taper angle: promoting green manufacturing and chemistry[J]. Applied Energy, 2025, 377: 124452. doi: 10.1016/j.apenergy.2024.124452
    [15]
    Webster T J, Ergun C, Doremus R H, et al. Specific proteins mediate enhanced osteoblast adhesion on nanophase ceramics[J]. Journal of Biomedical Materials Research, 2000, 51(3): 475-483. doi: 10.1002/1097-4636(20000905)51:3<475::AID-JBM23>3.0.CO;2-9
    [16]
    Vorobyev A Y, Guo Chunlei. Femtosecond laser structuring of titanium implants[J]. Applied Surface Science, 2007, 253(17): 7272-7280. doi: 10.1016/j.apsusc.2007.03.006
    [17]
    Dumas V, Rattner A, Vico L, et al. Multiscale grooved titanium processed with femtosecond laser influences mesenchymal stem cell morphology, adhesion, and matrix organization[J]. Journal of Biomedical Materials Research Part A, 2012, 100A(11): 3108-3116.
    [18]
    Trtica M, Batani D, Redaelli R, et al. Titanium surface modification using femtosecond laser with 1013-1015 W/cm2 intensity in vacuum[J]. Laser and Particle Beams, 2013, 31(1): 29-36.
    [19]
    Dumas V, Guignandon A, Vico L, et al. Femtosecond laser nano/micro patterning of titanium influences mesenchymal stem cell adhesion and commitment[J]. Biomedical Materials, 2015, 10: 055002. doi: 10.1088/1748-6041/10/5/055002
    [20]
    Luo Fengxiong, Wang Ling, Xiao Zhanwen, et al. Application of femtosecond laser microfabrication in the preparation of advanced bioactive titanium surfaces[J]. Journal of Materials Chemistry B, 2021, 9(18): 3912-3924. doi: 10.1039/D1TB00231G
    [21]
    Papa S, Khalil A A, Hamzeh-Cognasse H, et al. Dual-functionalized titanium by ultrafast laser texturing to enhance human gingival fibroblasts adhesion and minimize Porphyromonas gingivalis colonization[J]. Applied Surface Science, 2022, 606: 154784. doi: 10.1016/j.apsusc.2022.154784
    [22]
    Guo Weiwei, He Xu, Song Jianye, et al. Multiscale hierarchical micro- and nano-surface induced by high-repetition-rate femtosecond laser promote peri-implant osseointegration[J]. ACS Applied Bio Materials, 2025, 8(2): 1621-1634. doi: 10.1021/acsabm.4c01759
    [23]
    郭维维, 刘富伟, 何煦, 等. 尖锐无序vs. 圆钝有序钛表面微纳米结构的构筑及其成骨能力的评估[J]. 实用口腔医学杂志, 2025, 41(3): 336-343 doi: 10.3969/j.issn.1001-3733.2025.03.006

    Guo Weiwei, Liu Fuwei, He Xu, et al. Fabrication of sharp disordered vs. rounded ordered titanium surface micro- and nano-structures and evaluation of their osteogenic capacity[J]. Journal of Practical Stomatology, 2025, 41(3): 336-343 doi: 10.3969/j.issn.1001-3733.2025.03.006
    [24]
    Lackington W A, Schweizer P, Khokhlova M, et al. Femtosecond laser-texturing the surface of Ti-based implants to improve their osseointegration capacity[J]. Advanced Materials Interfaces, 2022, 9: 2201164. doi: 10.1002/admi.202201164
    [25]
    Wu Xinhui, Ao Haiyong, He Zhaoru, et al. Surface modification of titanium by femtosecond laser in reducing bacterial colonization[J]. Coatings, 2022, 12: 414. doi: 10.3390/coatings12030414
    [26]
    Lin Xiaoming, Li Xiaohong, Li Guoqiang, et al. Micro-dot-matrix induced by femtosecond laser on titanium surface for Ca-P phase deposition[J]. Applied Surface Science, 2020, 499: 143925. doi: 10.1016/j.apsusc.2019.143925
    [27]
    Rodríguez Á, Trueba P, Amado J M, et al. Surface modification of porous titanium discs using femtosecond laser structuring[J]. Metals, 2020, 10: 748. doi: 10.3390/met10060748
    [28]
    Liu Yang, Rui Zhongying, Cheng Wei, et al. Characterization and evaluation of a femtosecond laser-induced osseointegration and an anti-inflammatory structure generated on a titanium alloy[J]. Regenerative Biomaterials, 2021, 8: rbab006. doi: 10.1093/rb/rbab006
    [29]
    Wang Su, Zhang Miao, Liu Linlin, et al. Femtosecond laser treatment promotes the surface bioactivity and bone ingrowth of Ti6Al4V bone scaffolds[J]. Frontiers in Bioengineering and Biotechnology, 2022, 10: 962483. doi: 10.3389/fbioe.2022.962483
    [30]
    Lee J S, Son K, Hwang S M, et al. Effect of electrocautery and laser treatment on the composition and morphology of surface-modified titanium implants[J]. Bioengineering, 2023, 10: 1251. doi: 10.3390/bioengineering10111251
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