The fabricating technology of Ar ion beam etching for largearea microlens array of 128×128 in ZrO2, InP, Si, and SiO2 substrates, was discussed in this paper. The experimental results showed that the experimental conditions of fabricating microlens array with the pdeterminating parameters in the different substrates were different. The experimental relations between the ionbeametching rate and ionbeam energy, and the SEM photograph of Si microlens array, were given.