Abstract: In order to investigate the irradiation effects of heavy particles on hollow glass microspheres (HGMs) used in inertial confinement fusion (ICF) and the mechanism during filling gas, the molecular dynamics method was used to simulate the formation of micro-channels before and after irradiation in silica glass. The simulation results show the irradiation of heavy particles have produced obvious channels in silica glasses, which will be better for filling argon gas; the particle channels produced by irradiation have gradually closed under high temperature and high pressure, and the irradiation defects have recovered in some degree. Therefore, the irradiation of heavy particles can produce micro-channels for filling gas, and they can be closed under high temperature and high pressure, which plays the role of a switch. The results provide theoretical support for the experiment of gas filling and barrier properties of microspheres, and also testify the feasibility of the method.