Abstract: To describe morphological changes in the drilling hole and simulate the temperature distribution during nanosecond laser drilling, a physical model of titanium nanosecond-pulsed laser drilling was established and programmed using ANSYS Parametric Design Language (APDL). Elements birth and death technology was applied to simulate the drilling process in the finite element analysis software ANSYS. Experimental and simulation results were compared, and curve changes in the laser drilling results (hole depth and diameter) together with laser machining parameters (laser energy and pulse number) were obtained and investigated. Effects of process parameters on hole quality are analyzed and compared from finite element simulation and experiment to optimize process parameters and improve hole quality. The universal law of nano-second pulsed laser drilling on titanium alloy is discussed systematically.