Abstract: In this paper, a real-time vacuum measurement system is designed for the static vacuum maintaining and repetition frequency operation of Magnetically Insulated Transmission Line Oscillator(MILO). By optimizing the conventional vacuum measurement method, this system realizes the real-time monitoring of vacuum and data acquisition. Experiments of real-time vacuum measurement in the MILO were carried out on a 30 GW pulse power driver. Results show that this system has good anti-electromagnetic interference ability. Meanwhile, accurate pressures and pulse deflation characteristics can be well obtained. Under repetition frequency operation, this vacuum measurement system can provide technical support for parameter diagnosis of HPM sources.