Abstract: In order to study the associated particle imaging technique, it is necessary to develop the first-generation associated particle tube with the associated particle detector. Therefore, the key techniques, such as D-T generator, the relationship between neutrons and alpha particles in D-T reaction, associated particle detector and readout circuit, are studied. The performance of the position sensitive photomultiplier (PSPMT)and two readout circuits are tested in the experiment and design of the first-generation associated particle tube with the associated particle detector. It is proved that the SCDC readout circuit has smaller distortion and higher position resolution than the DPC readout circuit. The association between alpha particles and neutrons in time and position is measured, and the neutron angle uncertainty is about 7°, which is consistent with the theory ethical value.