Abstract: The material parameters and functional modules of LiF are added to the two-dimensional magnetically driven simulation code (MDSC2), which makes MDSC2 code have the ability to simulate the magnetically driven quasi-isentropic compression experiments with windows. Magnetically driven experiments with windows, shots of exp-3-window and exp-6-window, which were carried out in a large pulsed power device, are simulated and analyzed by the MDSC2 code. The simulated flyer plate/window interface velocities agree well with the experimental records by Velocity Interferometry System for Any Reflector (VISAR). The magneto-hydrodynamic code can correctly simulate the magnetically driven experiments with windows, which is helpful to understand the physical mechanism of sample material behaviors in magnetically driven experiments with windows.