Abstract: To establish a monochromatic high-energy proton photography platform on high power laser device with hundreds of kilojoules, D³He gas-filled spherical SiO₂ glass pellets, irradiated by an absorbed laser intensity of 10¹⁵ W/cm² have been considered and the exploding pusher target simulation has been conducted with Helios-CR to design an optimum target, which couples to the incident laser light more effectively to produce the optimum number of protons. By varying the inner radius of the target, the laser intensity and the thickness of the spherical shell, the optimal laser conditions and target parameters for photography under the condition of our laser device are obtained. The simulation results give a suitable experimental parameter of 300 μm target ball radius, 1.8 MPa filled D³He gas and 3.5 μm SiO₂ spherical shell thickness. In addition, we also considered the influence of laser driving symmetry and kinetic effect on the simulation results. Taking the optimal parameters obtained by simulation as the input, it is expected that 10⁹–10¹⁰ proton yield can be obtained experimentally. The law of proton yield variation obtained through simulation provides a reference for the formal establishment of the proton photography platform and the selection of experimental parameters.