Abstract: In the past decades, great progress has been made in laser wakefield acceleration of electron beam inspired by ultra-short intense lasers in plasma. The high-energy electron beam obtained by this method can be applied to the generation of the high-brightness and intense radiation sources, which have attracted extensive attention. In this paper, the basic principle and research status of Betatron radiation generated by laser wakefield acceleration are briefly introduced. The development trend of Betatron radiation is analyzed in combination with the X-ray application requirements. It is found that there is an urgent need to develop a new scheme of laser wakefield electron acceleration based on compact laser device to break through the limit of beam-loading effect on electron charge. By this means, one can generate large charge electron beam and high flux Betatron radiation source. Finally, a new scheme is briefly introduced to generate 10 nC high-energy electron beam and the photon number of Betatron radiation source reach 1.0\times 10^12 /shot using hundreds of TW femtosecond laser by a joint team led by Professor Yan Xueqing at Peking Univesity.