Abstract: There are several issues with traditional microchannel plate (MCP) gated framing cameras used for inertial confinement fusion diagnostic, such as large volume, incapable single line-of-sight (SLOS), and so on. The MCP can be instead by a CMOS chips with time resolution of picosecond-scale to achieve the image with SLOS. This paper presents a SLOS four-frame picosecond CMOS circuit consisting of 8×8×4 pixel arrays, and its performance is simulated. The CMOS circuit includes the design of unit pixel which contains four-frame, delay and control circuitry, binary clock tree, circuitry of row and column selector by using 0.18 μm CMOS process and 5T (5 transistors) unit pixel. The signals in the pixel array of the CMOS circuit are analyzed, ans the simulation results show that the CMOS circuit has the capability to obtain four images with a single exposure. The temporal resolution is 100 ps, the interval between two adjacent images is 300 ps, and the uniformity of intra-pixel signals is better than 90%.