Abstract: Shields are widely used in EMC applications because they can realize electromagnetic shielding, but few studies have focused on the effect of shields on electromagnetic crosstalk in a double differential mode loop, consisting of independent power loop and signal loop. A crosstalk analysis model based on the theory of multi-conductor transmission lines is proposed. In this method, the per-unit-length equivalent circuit model of the system is established, then the transmission line equations of the system are written by using the idea of finite difference and Kirchhoff’s voltage law and current law, and the crosstalk results are obtained finally. The crosstalk results are compared with the simulation results obtained by CST software to verify the feasibility and validity of the model and calculation method. Separate calculations of inductive coupling and capacitive coupling are carried out to study the effect of shielding layer on electromagnetic crosstalk between cables, and crosstalk suppression methods are obtained, which can provide guidance for the selection of cables and the selection of shield grounding method in practical engineering applications.