Abstract: The recent development of neutron generation and diagnostics of fast Z-pinch are reviewed. The principle and configuration of fusion and fission hybrid reactor are briefly introduced. Current and magnetic impulse modeling and the debris shield design are examined for the interface between Z-pinch driver and hybrid reactor. The conclusion of this work is that the interface of post hole convolute and extended coaxial magnetically insulated transmission line is feasible and easily operated at primary test stand (PTS).