Abstract:
Background Boron neutron capture therapy (BNCT) dose simulation is the cornerstone for equipment development, drug iteration, and clinical trials.
Purpose To meet the need for BNCT dose simulation and analysis based on clinical CT, we propose and build a brand-new BNCT dose simulation system.
Methods Within the medical-image platform MeVisLab, we complete DICOM registration, target delineation, and RTStruct/RTDose interfaces; the open-source Monte Carlo code OpenMC is used as the engine to execute neutron-transport simulation, realizing HU-to-material mapping and variable-mesh calculation.
Results Validation with clinical CT data simulated by the system shows that at a depth of 22 cm in the tumour target, the boron dose accounts for 80.9% of the total dose.
Conclusions Developed within weeks and with low licence costs, the system provides an efficient calculation tool for BNCT dose simulation and a reference framework for BNCT dose simulation in research and education.
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